Downstream synthetic route of 29182-42-1

The synthetic route of 29182-42-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29182-42-1,Ethyl 2-(benzo[d]thiazol-2-yl)acetate,as a common compound, the synthetic route is as follows.,29182-42-1

General procedure: To an oven-dried and argon-filled Schlenk tube was added 2-substituted benzo[d]thiazole component 1 (0.5 mmol), 2-bromoenal 2 (0.75 mmol, 1.5 equiv), triazolium salt C (0.05 mmol,10 mol%), and DIPEA (0.6 mmol, 1.2 equiv) in toluene (5 mL).The mixture was stirred at r.t. and monitored by TLC until completion of the reaction. The residue was purified by flash chromatography on silica gel [n-pentane-Et2O (10:1) or n-pentaneCH2Cl2 (1:1 to 1:2)] to afford the products 3a-k as orange oryellow solids.

The synthetic route of 29182-42-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ni, Qijian; Xiong, Jiawen; Song, Xiaoxiao; Raabe, Gerhard; Enders, Dieter; Synlett; vol. 26; 11; (2015); p. 1465 – 1469;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica