With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.94284-66-9,1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.
General procedure: 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone (1 mol) in methanol (4.0-4.1 l), was added dropwise to a cooled solution of corresponding aromatic aldehydes (1 mol) in 10% NaOH (600-650 ml). The solution was maintained at 0 C for 1.5 h and then was allowed to stir at room temperature. After some time (5-12 h) solid started separating out. The solid was filtered under vacuum and recrystallized from dioxane or ethanol to give the title chalcones. The yield range after recrystallization of chalcones was 32-84%., 94284-66-9
As the paragraph descriping shows that 94284-66-9 is playing an increasingly important role.
Reference£º
Article; Liaras; Geronikaki; Glamo?lija; ?iri?; Sokovi?; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3135 – 3140;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica