7238-61-1,7238-61-1, 2-Bromo-4-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A dioxane (10.00 mL) mixture of a compound WX022-1 (206.90 mg, 1.50 mmol), a compound WX022-2 (222.56mg, 1.25 mmol), [1,1?-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (94.16 mg, 0.125 mmol) and sodium carbonate(264.98 mg, 2.50 mmol) was reacted at 85 C for 3 hours under the protection of nitrogen. After the reaction wascompleted, the mixture was cooled down and 1M hydrochloric acid was added to adjust the pH to 6. The mixture wasdiluted with 10 mL of water, and extracted with 20mL of ethyl acetate twice, and the water phase was adjusted withNaHCO3 (aq) to a pH of 8. Then the mixture was extracted with 20mL of ethyl acetate twice, dried with anhydrous sodiumsulfate and spin-dried to obtain the compound WX022-3. 1H NMR (400MHz, CHLOROFORM-d) delta = 7.81 (br d, J=7.8Hz, 2H), 6.90 (br d, J=8.3 Hz, 1H), 6.94-6.87 (m, 1H), 6.80 (s, 1H), 2.49 (s, 3H).
7238-61-1 2-Bromo-4-methylthiazole 551541, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica