With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7210-76-6,Ethyl 2-amino-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
7210-76-6, A mixture of 2-amino-4-methyl-thiazole-5-carboxylic acid ethyl ester (1.0 g, 5.4 mmol) inN,N-dimethylformamide at [25 oC] was treated with triethylamine (1.89 mL, 13.5 mmol) and triphenylmethylchloride (1.66 g, 5.94 mmol). The reaction was stirred at [2 oC] for 2 days. At this time, the reaction was concentrated in vauco. The residue was dissolved in dichloromethane (100 mL) and was washed with a IN aqueous hydrochloric acid solution (1 x 20 mL), a saturated aqueous sodium bicarbonate solution [(1] x 20 mL), and a saturated aqueous sodium chloride solution [(1] x 20 mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo to afford 4-methyl-2- (trityl-amino)-thiazole-5-carboxylic acid ethyl ester (2.3 g, quant.). The product was used without further purification: LR-MS for [C26H24N202S] [(M-H) +] at [RN/Z = 427.]
7210-76-6 Ethyl 2-amino-4-methylthiazole-5-carboxylate 343747, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica