1477-42-5, 4-Methylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add commercially available 2-amino-4-methy-benzothiazole (10 g, 61 mmol) portionwise to a black solution of copper (II) bromide (16 g, 73 mmol) and TERT-BUTYL nitrite (11.9 mL, 99 mmol) in acetonitrile (220 mL) at room temperature under nitrogen over the course of five min and stir the mixture for 30 min. Dilute the mixture with 1 N HCL (500 mL) and extract with ethyl acetate (3 x 500 mL). Wash the combined organic extracts with 1 N HCL (250 mL), dry over MGS04 and remove the solvents under reduced pressure. Purify the residue by filtration through a plug of silica gel, eluting with ethyl acetate (500 mL), and remove the solvents under reduced pressure to afford 2-bromo-4-methylbenzothiazole (Step 1) as a black solid (12.68 g, 91%): 1H NMR (CDCL3) 6 2.70 (s, 1H), 7.20 (m, 2H), 7.60 (d, 1H) ; APCI mass spectrum M/Z 228 [C8H6NSBR + H] +., 1477-42-5
As the paragraph descriping shows that 1477-42-5 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/63155; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica