With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-74-6,2-Chloro-6-fluorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
Example 3: N-[(/5^25)-2-[(6-Fluoro-l<3-benzothiazol-2-vl)amino1cvclopentyl1-2<6- dimethoxybenzamide A microwave vial was charged N-((iS,2S)-2-aminocyclopentyl)-2,6-dimethoxybenzamide hydrochloride (Intermediate 11; 80 mg, 0.266 mmol), DIPEA (0.26 ml, 0.266 mmol) and 2-chloro-6-fluoro-l,3-benzothiazole (50 mg, 0.266 mmol) and the resulting mixture was heated with microwave irradiation at 250 C for 20 minutes. The reaction was purified by reverse phase preparative HPLC eluted with acetonitrile / water (with 0.1% ammonia) to afford the title compound.1H NMR (DMSO- e) delta ppm 1.48 - 1.77 (m, 4 H), 2.02 - 2.14 (m, 2 H), 3.62 (s, 6 H), 4.09 - 4.27 (m, 2 H), 6.51 - 6.65 (m, 2 H), 7.03-7.05 (m, 1 H), 7.18 - 7.38 (m, 2 H), 7.59 (m, 1 H) and 8.12-8.15 (m, 2 H)MS ES+: 416 399-74-6, The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica