Downstream synthetic route of 41731-83-3

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,41731-83-3

Synthesis of ethyl 2-piperazin-1-ylthiazole-5-carboxylate 1.02 g (5.0 mmol) of ethyl 2-bromothiazole-5-carboxylate and 4.31 g (50 mmol) of piperazine were dissolved in ethanol (20 ml) and the mixture was heated under reflux over a period of 4 h. The solution was then concentrated in vacuo, taken up in EA and washed successively with water and a satd aq. NaCl solution. Following drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo there were obtained 1.12 g (4.6 mmol, 93%) of ethyl 2-piperazin-1-ylthiazole-5-carboxylate.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica