Application of 349-49-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 349-49-5, Name is 4-(Trifluoromethyl)thiazol-2-amine, molecular formula is C4H3F3N2S. In a Article，once mentioned of 349-49-5
The activation of the NF-kappaB transcription factor is a major adaptive response induced upon treatment with EGFR kinase inhibitors, leading to the emergence of resistance in nonsmall cell lung cancer and other tumor types. To suppress this survival mechanism, we developed new thiourea quinazoline derivatives that are dual inhibitors of both EGFR kinase and the NF-kappaB activity. Optimization of the hit compound, identified in a NF-kappaB reporter gene assay, led to compound 9b, exhibiting a cellular IC50 for NF-kappaB inhibition of 0.3 muM while retaining a potent EGFR kinase inhibition (IC50 = 60 nM). The dual inhibitors showed a higher potency than gefitinib to inhibit cell growth of EGFR-overexpressing tumor cell lines in vitro and in a xenograft model in vivo, while no signs of toxicity were observed. An investigation of the molecular mechanism of NF-kappaB suppression revealed that the dual inhibitors depleted the transcriptional coactivator CREB-binding protein from the NF-kappaB complex in the nucleus.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 349-49-5 is helpful to your research., Application of 349-49-5
Reference：
Thiazole | C3H4913NS – PubChem,
Thiazole | chemical compound | Britannica