106092-09-5, (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Starting compound (S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine(29)(4.00g;23.6mmol)was dissolved in tetrahydrofuran(THF) (30mL)and cooled in an icebath to 0C.Then di-tert-butyldicarbonate (5.42 g, 24.8 mmol) dissolved in THF (15 mL) was added dropwise. The reaction mixture was stirred for 60 h at room temperature. The solvent was removed under reduced pressure. Yield: 99.8% (6.35g),palebrownamorphoussolid.[alpha]D25 -56.8(c0.42,MeOH). 1HNMR(400MHz,DMSO-d6)delta1.39(s,9H,3¡ÁCH3),1.52-1.68(m, 1H, 5-CH2), 1.80-1.90 (m, 1H, 5-CH2), 2.30-2.48 (m, 3H, 4-CH2, 7CH2),2.69(dd,J7,7? =14.9Hz,J7,6 =5.3Hz,1H,7-CH2),3.57-3.70 (m,1H,6-CH),6.65(s,2H,NH2),6.95(d,J=7.7Hz,1H,CONH)ppm. 13C NMR (100 MHz, DMSO-d6) delta 24.9, 28.2, 28.9, 46.8, 77.6, 112.4, 144.1, 154.9, 166.1 ppm. MS (ESI + ): m/z = 292.4 ([M + Na]+), 214.2(100%).
106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Gjorgjieva, Marina; Kikelj, Danijel; Liekens, Sandra; Lillsunde, Katja-Emilia; Naesens, Lieve; Lamut, Andra?; Tammela, Paeivi; Toma?i?, Tihomir; Bioorganic Chemistry; vol. 98; (2020);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica