With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3581-89-3,5-Methylthiazole,as a common compound, the synthetic route is as follows.
To a solution of BuLi (1.6 M in hexanes, 12.6 mL, 20.2 mmol) in 25mL of diethyl ether at -78 0C, was added a solution of 5-methylthiazole (2.0 g, 20.2 mmol) in ether (6 mL), drop-wise and stirred at -78 0C for 1.5 h. A solution of DMF (2.33 mL, 30.3 mmol in ether (5 mL) was added at once and the reaction mixture was allowed to warm to room temperature and stirred overnight. Ice was added to the reaction mixture followed by the slow addition of 4N HCl. The mixture was taken up in a separating funnel, ether added (30 mL) and shaken. The organic layer was discarded. The aqueous layer was brought to pH -7.5 with solid NaHCO3 and extracted with ether twice. The ether layer was dried over Na2SO4 and concentrated, and the resulting crude 5-methylthiazole-2-carbaldehyde (1.6 g) was carried over to the next- step without purification., 3581-89-3
The synthetic route of 3581-89-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica