41731-23-1, 2-Bromo-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,41731-23-1
Intermediate 8 (5.2 g, 14.9 mmol), 2-bromo-5-methyl-1,3-thiazole (1.87 mL, 17.9 mmol) and cesium carbonate (12.2 g, 37.3 mmol) were dissolved in 4:1 1,4- dioxane/water (75 mL). The solution was degassed with a stream of nitrogen for 10 mi Tetrakis(triphenylphosphine)palladium(0) (517.7 mg, 0.45 mmol) was addedand the reaction mixture heated at 100 C overnight. The reaction mixture was diluted with water (100 mL) and extracted with DCM (2 x 100 mL). The combined organics were dried (MgSO4), filtered and concentrated under reduced pressure. The crude material was purified by Biotage IsoleraTM chromatography (eluting with 1 – 40 % EtOAc in heptane on a 100 g KP-Si02 column) to give the title compound3.06 g (64 % yield) as a yellow solid.1H NMR (250 MHz, Chloroform-d): 6 [ppm] 8.11 (t, J = 1.4 Hz, 1H), 7.67 – 7.63 (m, 1H), 7.55 (dd, J = 2.5, 1.4 Hz, 1H), 7.52 (d, J = 1.2 Hz, 1H), 5.07 (td, J = 4.1, 2.2 Hz, 1H), 4.11 – 3.86 (m, 7H), 2.53 (d, J = 1.1 Hz, 3H), 2.35 -2.09 (m, 2H).LCMS (Analytical Method A) Rt = 1.34 mm, MS (ESIpos): m/z = 320 (M+H).
The synthetic route of 41731-23-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica