With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-43-6,Ethyl thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
The thiazole-4-methanol used as a starting material was prepared as follows:- Lithium aluminium hydride (1M solution THF, 1.5 mL) was added slowly to a stirred solution of ethyl thiazole-4-carboxylate (224 mg) in THF (4 mL) cooled to 0C. The reaction mixture was stirred and allowed to wann to room temperature over 1 hour. Ethyl acetate (20 mL) was added to the reaction mixture followed by water (1 mL), 2M NaOH solution (2 mL) then water (3 mL). A precipitate formed which was filtered off through Celite (iT). The filtrate was concentrated to give the title compound (150 mg, 92%); NMR Spectrum : (DMSOd6) 4.12 (s, 2H), 7.47 (s, 1H), 9. 03 (s, 1H)., 14527-43-6
As the paragraph descriping shows that 14527-43-6 is playing an increasingly important role.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica