With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14190-59-1,Thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Preparation 107: 1, 3-thiazole-2-carbonyl CHLORIDE 1,3 thiazole-2-carboxylic acid (Preparation 92,5. 0 g, 39 MMOL) was added to a solution containing sodium hydroxide (1.55 g), in water (26 ml). The solution was evaporated to dryness and the resultant solid was triturated with diethyl ether, filtered and dried in an oven at 60 C for 6 h to give a brown solid (5.5 g). The solid was added to thionyl chloride (25 ML) and heated on a steam bath for 2 h. The excess thionyl chloride was removed in vacuo and the resultant oil was triturated with petroleum ether (40-60,3 x 30 ml) to give the title compound as an oily solid upon filtration and evaporation (4.0 g, 70percent).
14190-59-1, As the paragraph descriping shows that 14190-59-1 is playing an increasingly important role.
Reference：
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/72086; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica