Downstream synthetic route of 31785-05-4

The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.

31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

ethyl 2-methyl-5- (f [ (trichloroacetyl) aminolcarbonyllamino)-1, 3-thiazole-4-carboxylate.; To a stirred solution of ethyl 5-amino-2-methyl-1, 3-thiazole-4-carboxylate (1 equiv) in anhydrous THF (10 mL) was added trichloroacetyl isocyanate (1 eq) slowly over a period of 5 min. After the addition was complete, a precipitate formed and the reaction stirred for an additional lh. The desired product was obtained by filtration (99% yield) as a yellow solid. The product was used in the next step without any further purification. LC/MS (ES, M+H=374)., 31785-05-4

The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/66163; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica