182344-56-5, 2-Chloro-4-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of (lS,3S)-3-((3-(tetrahydro-2H-pyran-4-yl)pyrazin-2- yl)oxy)cyclobutanamine hydrochloride (see PREPARATION 5D, 200 mg, 0.8 mmol) in NMP (4 mL) was added 2-chloro-4-fluoro-benzothiazole (150 mg, 0.8 mmol) and DIEA (229 mg, 1.6 mmol), then heated to 180C for 2 h in microwave. The reaction mixture was diluted with water (10 mL), extracted with ethyl acetate (20 mL), washed with water and brine, dried over Na2S04 and concentrated. The residue was purification by prep-HP C to give the title compound (30 mg, yield 9%)., 182344-56-5
182344-56-5 2-Chloro-4-fluorobenzo[d]thiazole 2049864, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica