103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 12-(5-Bromo-thiazol-4-yl)-5-methyl- 1 H-benzoimidazole A solution of 5-bromo-thiazole-4-carboxylic acid (1.37 g, 6.59 mmol, commercially available from Combi-blocks), diisopropylethylamine (1.49 mL, 8.57 mmol), 4-methyl-beiizene-1,2- diamine (0.88 g, 7.25 mmol) in DMF (11 mL) at room temperature was treated with TBTU (2.75 g, 8.57 mmol) and the mixture stirred at room temperature for 18 h. The solvents were thenevaporated under vacuum and the residue partitioned between ethyl acetate and saturated solution of sodium bicarbonate, the organics were collected and dried with magnesium sulfate and then concentrated under vacuum. The crude mixture was dissolved in acetic acid (12 mL), transferred to microwave vial and the mixture was heated at 150 C in a microwave reactor for 1.5 h. After solvent evaporation, the residue was dissolved in dichioromethane, washed with saturated solution of sodium bicarbonate, dried with magnesium sulfate and concentrated under vacuum to yield 2-(5-bromo-thiazol-4-yl)-5-methyl-1H-benzoimidazole (1.93 g, crude,quantitative yield for two steps) as a beige solid that was used into the next step without further purification. ?H NMR (CHLOROFORM-d) 3: 8.82 (s, 1H), 7.64 (d, J = 7.9 Hz, iH), 7.47 (s, 1H), 7.15 (d, J = 8.3 Hz, 1H), 2.50 (s, 3H); LCMS (El/Cl) m/z: 293.9, 295.9 [M + H]., 103878-58-6
The synthetic route of 103878-58-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BHAGIRATH, Niala; DOMINIQUE, Romyr; KENNEDY-SMITH, Joshua; LUCAS, Matthew C.; PADILLA, Fernando; WO2014/64134; (2014); A1;,
Thiazole | C3H3NS – PubChem
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