With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-55-3,Benzo[d]thiazol-7-amine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of aniline 1a (0.45 g, 0.005 mol), triethyl orthoformate (30 mL) and 2 mol of diphenyl phosphite (1.91 g, 0.01 mol) was stirred at 130 C for 2.5 h with continuous removal of ethanol formed. The reaction was monitored by TLC on silica gel using petroleum ether and ethyl acetate (1:2 v/v). After cooling, the volatiles were removed in vacuo. The residue was chromatographed on silica gel using CHCl3-MeOH (9:1).
1123-55-3, The synthetic route of 1123-55-3 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Balakrishna; Narayana Reddy, M. Veera; Rao, P. Visweswara; Kumar, M. Anil; Kumar, B. Siva; Nayak; Reddy, C. Suresh; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1798 – 1802;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica