With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30132-15-1,2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid,as a common compound, the synthetic route is as follows.
B. To prepare the intermediate methyl (2-amino-benzothiazol-6-yl)acetate, 2 mL concentrated H2SO4 was added dropwise to a solution of (2-amino-1,3-benzothiazol-6-yl)acetic acid (7.89 g, 37.9 mmol) in 200 mL methanol and the reaction mixture was heated at 50 C. for 90 minutes. After evaporation of most of the methanol, dichloromethane (150 mL) was added and the mixture was neutralized with saturated NaHCO3 solution. The aqueous phase was extracted with dichloromethane. The organic extracts were combined, dried over MgSO4, and concentrated to give the product as a yellow solid (6.51 g, 77%). 1H NMR (DMSO-d6) delta 7.54 (s, 1H), 7.44 (br, 2H), 7.27 (d, 1H), 7.09 (d, 1H), 3.66 (s, 2H), 3.61 (s, 3H); LC-MS: ESI 223 (M+H)+., 30132-15-1
30132-15-1 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid 757163, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.; US2007/232604; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica