With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.939-69-5,6-Hydroxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.
D-2-(6′-Hydroxybenzothiazol-2′-yl)-D2-5-(2,6-dibromo-4-cyanophenoxy)methylthiazoline-4-carboxylic acid.. A solution of 2-cyano-6-hydroxybenzthiazole (2.0 eq.) in MeOH is purged with nitrogen for 5 minutes.. A solution of (2R,3S)-2-amino-4-(2,4-dibromo4-cyanophenyl)oxy-3-mercaptobutanoic acid trifluoroacetate (1.0 eq.) and potassium carbonate (1.0 eq.) in deoxygenated water is added to the methanol solution.. The reaction is stirred under nitrogen while being protected from light for 2 hours.. The volume of the reaction is doubled with water and the resulting solution is made acidic with dilute hydrochloric acid.. The mixture is extracted with ethyl acetate.. The extract is washed with water and dried over sodium sulfate.. The solvent is removed and the residue is triturated with ether.. The residue is dried in vacuo to yield the title compound., 939-69-5
The synthetic route of 939-69-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Marker Gene Technologies, Inc.; US6656917; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica