921927-88-0, Methyl 2-formylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
921927-88-0, Lithium diisopropyl amide (?LDA,? 60 mL, 108 mmol, 1 .8M) was added to 200 mL of ether at -78 C. followed by the addition of sulfinimine 7 (18.9 g, 100 mmol) in 200 mLether and the resultant reaction mixture was stirred for 40 mi C1Ti(OiPr)3 (203 mmol, 48.4 mL) was added to the reaction mixture and the solution was stirred for 60 mm. A solution of methyl 2-formylthiazole-4-carboxylate 4 (12.5 g, 72.6 mmol) in 180 mL of THF was added slowly to thereaction mixture. Afier another 2 h at -78 C., a mixture of acetic acid and THF (?A v/v, 4.9 mL) was added. The mixturewas warmed to 5 C. over 1 h and then poured into brine solution. The desired product was then extracted from the brine solution with ether and EtOAc solution. The organic phase was then dried over anhydrous MgSO4, filtered and evaporated. The residue was passed through 2 columns (DCM:EtOAc and hexane:EtOAc) to give compound 8 (19.6 g, 54 mmol, 75%) as an oil. MS (ES+) mlz, calculated: m+1, 361.12. found, 361.
The synthetic route of 921927-88-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; E. R. SQUIBB & SONS, L.L.C.; Cheng, Heng; Gangwar, Sanjeev; Cong, Qiang; (82 pag.)US9226974; (2016); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica