With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
2-[(1-Benzothiazol-6-yl-methanoyl)-amino]-3-phenyl-propionic acid Benzothiazole-6-carboxylic acid (2h, 258 mg) is dissolved in dichloromethane (10 ml), and treated with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (345 mg). The reaction is stirred for 10 minutes. 1-Hydroxybenzotriazole (244 mg) is added and the mixture is stirred for a further 10 minutes. L-Phenylalanine t-butyl ester hydrochloride (200 mg) is added and the reaction maintained at room temperature for 72 hours. The mixture is concentrated, the residue taken up in ethyl acetate and washed with water, sodium bicarbonate, and brine. The organic phase is dried (MgSO4), concentrated, and then purified by chromatography on silica (10% diethyl ether/DCM). This afforded the ester intermediate as a solid (60 mg).
3622-35-3, 3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; The Procter & Gamble Company; US2004/6104; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica