With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.
To a stined solution of 2-bromo-6-methoxybenzo[d]thiazole (8.00 g, 32.8 mmol) in dichloromethane (20 mL) at 15 C was added tribromoborane (9.1 mL, 98 mmol) dropwise. The resulting mixture was heated at 40 C for 6 h then poured into ice water. The precipitate was filtered and the filtrate was extracted with dichloromethane (40 mL x 3). The precipitate and the organic layers were combined, dried over Na2504,and concentratedto give the title compound.MS: m/z = 229.9, 231.9 (M + 1). ?H NMR (400 MHz, CD3OD): oe7.74 (d, J= 8.8 Hz, 1H), 7.28 (d,J=2.4Hz, 1H),7.00(dd,J,=8.8Hz, J2=2.4Hz, 1H)., 2941-58-4
The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica