3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 114 – preparation of N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)benzo[d]thiazole-6-carboxamide[00151] HATU (695 mg, 1 .83 mmol) was added to Compound 2 (400 mg, 1 .41 mmol), benzo[d]thiazole-6-carboxylic acid (290 mg, 1 .62 mmol) and DIPEA (0.737 mL, 4.22 mmol) in DMA (15 mL) and the resultant mixture stirred at ambient temperature for 16 hours under an inert atmosphere. The reaction mixture was diluted with EtOAc (300 mL), and washed with water (2 x 200 mL). The organic layer was dried over Na2S04, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 20 to 100% EtOAc in isohexane. The pure fractions were evaporated to a yellow solid which was triturated with DCM and filtered to afford the desired material as a white solid (287 mg, 46 %). 1H NMR (400 MHz, DMSO) delta 10.05 (s, 2H), 9.57 (s, 1 H), 8.82 (d, J= 1 .5 Hz, 1 H), 8.23 (d, J= 8.5 Hz, 1 H), 8.15 (dd, J = 1 .74, 8.6 Hz, 1 H), 7.87 (d, J = 2.1 Hz, 1 H), 7.58 – 7.65 (m, 1 H), 7.47 – 7.57 (m, 2H), 7.24 (d, J= 8.42 Hz, 1 H), 6.98 (d, J= 8.37 Hz, 1 H), 4.32 (m, 4H), 2.24 (s, 3H). m/z (ES+), (M+H)+ = 446.
3622-35-3, The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica