With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
96929-05-4, 33.5 g (0.18 mol) of thiazolyl ester are dissolved in 140 ml of methanol and 3 ml of water and, at 5-10 C., ammonia is introduced until the solution is saturated. The reaction mixture is stirred at room temperature overnight. The solvent is evaporated and the residue is, at 80 C., taken up in 100 ml of n-butanol. The mixture is cooled to 0 C. The precipitate is filtered off with suction, washed twice with in each case 35 ml of n-butanol and twice with in each case 35 ml of MTBE and dried under reduced pressure. Yield 17.3 g (58%), yield corrected for purity: 55% based on the thiazolidine employed. 1H-NMR (DMSO-d6): delta=8.2 (s, 1H, SCHCOOEt), 7.6, 7.7, 7.8 (3*s, 3*1H, 3*NH), 4.4 (s, 2H, CH2NH), 1.4 (s, 9H, tert-butyl) ppm.
As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.
Reference：
Patent; Abbott GmbH & Ci, KG; US6639081; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica