With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5304-21-2,6-Bromo-2-methylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,5304-21-2
In dioxane (10 mL) were suspended under nitrogen atmosphere 6-bromo-2-methylbenzothiazole 53 (700 mg, 3.07 mmol), Pd2(dba)3 (141 mg, 0.153 mmol) and Xantphos (178 mg, 0.307 mmol). To the obtained mixture was added thiophenol sodium salt (487 mg, 3.68 mmol). It was stirred at 130 ¡ãC for 15 minutes under microwave irradiation. .To the reaction mixture were added 0.1N hydrochloric acid and ethyl acetate. After extraction, the organic layer washed with saturated sodium bicarbonate aqueous solution and brine, respectively and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified with column chromatography to give Compound 55 (587 mg, 2.28 mmol). 1H-NMR (CDCl3) delta: 2.85 (s, 3H), 7.24-7.39 (m, 5H), 7.46 (dd, J= 8.6, 1.8 Hz, 1H), 7.83 (dd, J= 1.8, 0.5 Hz, 1H), 7.89 (d, J=8.6 Hz, 1H).
The synthetic route of 5304-21-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shionogi & Co., Ltd.; EP2351744; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica