80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80945-86-4
Intermediate 32:6-bromo-W-{6-chloro-4-[(2-methyl-1 H-imidazol-1 -yl)methyl]-2-pyridinyl}-1 ,3- ineUnder an atmosphere of nitrogen, an ice-cooled, stirred suspension of 6-chloro-4-[(2- methyl-1 H-imidazol-1-yl)methyl]-2-pyridinamine [intermediate 34] (1 .6g, 7.19mmol) in anhydrous tetrahydrofuran (40ml_) was treated with 6-bromo-2-chloro-1 ,3-benzothiazole (1.96g, 7.90mmol) and, portionwise over 5 minutes, with sodium hydride (60% in oil) (0.632g, 15.8mmol). After 30 minutes the mixture was heated to 50C for 6 hours. The cooled mixture was treated with saturated aqueous ammonium chloride (30ml_) and tetrahydrofuran (30ml_). The resulting precipitate was filtered off, washed with ethyl acetate and diethyl ether and dried to afford the title compound (2.2g, 5.06mmol, 70% yield). LCMS (Method A): Rt 0.94 minutes; m/z 434,436 (MH+).
The synthetic route of 80945-86-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ALDER, Catherine Mary; BALDWIN, Ian Robert; BARTON, Nicholas Paul; CAMPBELL, Amanda Jennifer; CHAMPIGNY, Aurelie Cecile; HARLING, John David; MAXWELL, Aoife Caitriona; SIMPSON, Juliet Kay; SMITH, Ian Edward David; TAME, Christopher John; WILSON, Caroline; WOOLVEN, James Michael; WO2011/110575; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica