With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103878-58-6,5-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
Intermediate 12 5-Bromothiazole-4-carboxylic acid (2.17g, 10.4mmol) was dissolved in dry dioxan (170ml_) and heated at 100C. To this, Lambda/,/V-dimethyl-formamide di-tert-butyl acetal (13.68g, 67.28mmol) was added drop wise and the mixture stirred at 100C for 1 hour. The mixture was cooled to room temperature and stirred for 18 hours. The volatile solvents were removed in vacuo and the residue partitioned between water and diethyl ether. The organic layer was washed with saturated NaHC03, dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-20% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 12 (2.8g) as a yellow solid. 1 H NMR (CDCIs) delta: 8.76 (1 H, s), 1 .63 (9H, s) LCMS (Method 2) Rt 3.23 min; m/z(M+H)+ 265
103878-58-6, 103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
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