With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-43-6,Ethyl thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
Methyl Iodide (140?mL, 2.25?mol, 5.0 equiv) was dissolved in Et2O (450?mL) and added dropwise to Mg turnings (54.3?g, 2.25?mol, 5.0 equiv) under a constant flow of nitrogen. When all magnesium dissolves ester 13 (70.24?g, 447?mmol) in Et2O (450?mL) was added dropwise. The reaction mixture was left overnight and resulted suspension was carefully (very exothermic + gas evolution.) was poured into saturated aqueous NH4Cl (~2?L). The resulted solution was extracted with Et2O (3?*?200?mL). The combined organic layers were dried over Na2SO4 and evaporated to give the pure compound. M?=?48.26?g. Yield?=?75%. 1H NMR: (CDCl3, 400?MHz) delta?=?1.61 (s, 6?H), 3.27 (br. s, 1?H), 7.17 (d, J?=?2.0?Hz, 1?H), 8.73 (d, J?=?1.8?Hz, 1?H). 13C NMR: (CDCl3, 100?MHz) delta?=?30.2 (2C), 71.2, 77.2, 111.6, 152.9, 165.0., 14527-43-6
The synthetic route of 14527-43-6 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Curreli, Francesca; Belov, Dmitry S.; Kwon, Young Do; Ramesh, Ranjith; Furimsky, Anna M.; O’Loughlin, Kathleen; Byrge, Patricia C.; Iyer, Lalitha V.; Mirsalis, Jon C.; Kurkin, Alexander V.; Altieri, Andrea; Debnath, Asim K.; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 367 – 391;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica