With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
To the solution of ethyl 2-[3-formyl-4-(2-methylpropoxy) phenyl]-4- methylthiazole-5-carboxylate compound of formula-12 (10 gms) in formic acid (40 ml) was added hydroxylamine hydrochloride (2.38 gms) and sodium formate (2.35 gms).Stirred the reaction mixture for 10 minutes. Heated the reaction mixture to 100C and stirred for four hours at same temperature. Cooled the reaction mixture to 25 C and quenched with water. Stirred the reaction mixture for 10 hours, filtered the precipitated solid and washed with water. Dried the material to get the title compound. Yield: 10 gms. Take the dry material, added 30 ml of ethyl acetate and heated to reflux temperature. Stirred the reaction mixture for 30 minutes at reflux temperature. Cooled the reaction mixture to 25C and filtered the precipitated solid. Dry the material to get the title compound as a pure material. Yield: 8.5 gms.
161798-03-4, As the paragraph descriping shows that 161798-03-4 is playing an increasingly important role.
Reference£º
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; VENKATA PANAKALA RAO, Gogulapati; PRASAD, Gadamsetty; WO2011/141933; (2011); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica