With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.
In a four-neck reactor equipped with a thermometer, in a nitrogen stream, 10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF. To this solution, Cesium carbonate 39.4 g (121.0 mmol) of 9.65 g of 1-bromo-2-butyne (72.5 m Mol) was added, and the whole mixture was stirred at 25 C. for 20 hours. After completion of the reaction, the reaction solution was washed with water 1000 m L and extracted with 500 ml of ethyl acetate. After drying the ethyl acetate layer with anhydrous sodium sulfate, Sodium sulfate was filtered off. In a rotary evaporator, Ethyl acetate was distilled off from the filtrate under reduced pressure to obtain a brown solid. The brown solid was purified by silica gel column chromatography (N-hexane: ethyl acetate = 85: 15) To obtain 6.25 g of Intermediate S (yield: 47.5%) as a white solid.
615-21-4, As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.
Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (78 pag.)JP6090514; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica