With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14779-17-0,2-Amino-5-methylbenzothiazole,as a common compound, the synthetic route is as follows.
3,3-difluoro-2-(phenylethynyl)-3H-indole II-1 (57.0 mg, was added sequentially to a 5 mL reaction flask.0.225 mmol), 5-methylbenzo[d]thiazol-2-amine III-2 (24.6 mg, 0.15 mmol), catalyst TBD (9.8 mg,0.075 mmol) and 1,1,2,2-tetrachloroethane (2.0 mL) were stirred at room temperature for 5 h. The TLC test material has basically been reacted and the reaction is stopped. The reaction solution is directly subjected to column chromatography.Eluent (ethyl acetate / dichloromethane = 1 / 20),Yellow solid product I-9 (47.5 mg) was obtained with a yield of 76%.
14779-17-0, 14779-17-0 2-Amino-5-methylbenzothiazole 26889, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Guangzhou University; Liu Yunlin; Lin Xiaotong; Mao Xiangyu; Chen Guoshu; (15 pag.)CN108586495; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica