With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1025700-49-5,2-Amino-5-bromo-4-isopropylthiazole,as a common compound, the synthetic route is as follows.,1025700-49-5
Step 3 5-Bromo-4-isopropyl-thiazole; Concentrated nitric acid (4 mL) was slowly added to 5-bromo-4-isopropyl-thiazol-2-yl- amine (2.05 g, 9 mmol), and concentrated phosphoric acid (14 mL) was added dropwise over 5 min. The mixture was cooled to -5C, and a solution of sodium nitrite (0.768 g, 11 mmol) in 5 mL water was added dropwise over a 15 min period. The reaction mixture was stirred at -5C for 30 min, and an aqueous solution of H3PO2 (6 mL, 50% weight in water) was slowly added. The reaction mixture was stirred at -5C for 2.5 h, then stirred at RT for 18 h. The reaction mixture was cooled to 00C and quenched by addition of aqueous NaOH (30% weight solution). The mixture was extracted with methylene chloride, and the combined organic extracts were washed with brine, dried (MgSO/O, filtered and concentrated under reduced pressure. The resulting oil was chromato- graphed (10% EtOAc in hexanes) to give 236 mg of 5-bromo-4-isopropyl-thiazole as an oil, MS (M+H) = 207.
As the paragraph descriping shows that 1025700-49-5 is playing an increasingly important role.
Reference：
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/55840; (2008); A1;,
Thiazole | C3H3NS – PubChem
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