With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144163-97-3,4-Nitrophenyl (thiazol-5-ylmethyl) carbonate,as a common compound, the synthetic route is as follows.
Compound 9a (20 g, 1.0 eq.), Compound 10 (34.4 g, 1.1 eq.) was added to methylene chloride (240 ml) and stirred at room temperature under nitrogen to give a clear solution. Diisopropylethylamine (17.3 g, 1.2 eq.) was added dropwise to the mixture, and the dropwise addition was completed. The reaction was incubated until the consumption of the starting material 9a was completed. The reaction mixture was washed sequentially with 1N hydrochloric acid (80 ml), saturated sodium bicarbonate (80 ml) and saturated brine (80 ml), and dried over anhydrous sodium sulfate. The mixture was filtered and the filtrate evaporated to remove the organic solvent under reduced pressure. The resulting crude solid was beaten for half an hour with t-butyl methyl ether (MTABE) (70 ml) and filtered. The resulting precipitate was dried to give compound 8a (32.38g, yield 90%)., 144163-97-3
The synthetic route of 144163-97-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye Tianjian; Lu Xiuwei; Liu Yongjiang; Wang Tong; Shu Zhan; (15 pag.)CN105198829; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica