Simple exploration of 2346-00-1

2346-00-1, As the paragraph descriping shows that 2346-00-1 is playing an increasingly important role.

2346-00-1, 2-Methyl-4,5-dihydrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2,4,4-Trimethyl-2-oxazoline 1 (1.50 g, 13.1 mmol, 1 eq.) was placed in a 100 mL flask, followed by dried THF (76 mL) and triethylamine (3.11 g, 30.6 mmol, 2.33 eq.). At ice bath temperature, (CF3CO)2O (6.52 g, 30.7 mmol, 2.34 eq.) was added dropwise over 23 min. The resulting suspension was refluxed for 5 h under nitrogen. Rotary evaporation was used to remove the solvent. Dichloromethane (30 mL) and saturated NaHCO3 (40 mL) were added to the residue and the mixture was stirred for 10 min. The organic layer was washed further with water (2 .x.40 mL). The organic layer was dried over anhydrous Na2SO4. After concentrating by rotary evaporation, the crude product was purified by flash column chromatography over silica gel, using mixed ethyl acetate/hexanes (2 : 1 volume ratio) as the eluting solvent. A white solid (1.34 g, 6.40 mmol) was obtained, yield 48.8percent.

2346-00-1, As the paragraph descriping shows that 2346-00-1 is playing an increasingly important role.

Reference:
Article; De Silva, Hondamuni I.; Song, Yingquan; Henry, William P.; Pittman Jr., Charles U.; Tetrahedron Letters; vol. 53; 24; (2012); p. 2965 – 2970;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica