4175-72-8,4175-72-8, 4-Chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation of 4-methoxythiazole (9): A mixture of sodium methoxide, prepared by treating 450 mL of methanol with 21 g (913 mmol) of sodium metal, and 29.3 g (245 mmol) of 4-chlorothiazole (8) was refluxed for 24 hours. The mixture was cooled to room temperature and was reduced in volume by about half by concentrating on a rotovap. The mixture was dissolved in 500 mL of water and extracted with diethyl ether (500 mL, then 3*200 mL). The combined ethereal extracts were washed with 500 mL of brine, dried over MgSO4, filtered, and concentrated in vacuo. The resulting red oil was purified by flash chromatography (silica gel, 5.5*30 cm, chloroform) and then by vacuum distillation to give 17.5 g (62% yield) of 4-methoxythiazole (9) as a colorless liquid. 1H NMR (500 MHz) delta 8.58 (d, 1H, J=2.2 Hz), 6.16 (d, 1H, J=2.3 Hz), 3.96 (s, 3H).
As the paragraph descriping shows that 4175-72-8 is playing an increasingly important role.
Reference:
Patent; Watson, Mark D.; US2010/252112; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica