64987-16-2, Methyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
64987-16-2, A solution of methyl 2-(2-aminothiazol-4-yl)acetate (3.56 g, 20.7 mmol) and DMAP (0.25 g, 2.07 mmol) in pyridine (16.74 ml_, 207 mmol) was cooled to 0 C whereupon methanesulfonyl chloride (1.61 ml_, 20.70 mmol) was added dropwise. The yellow solution was allowed to warm to RT and stirred for 1 hr then added to 1 M HCI (aq, 228 ml.) and stirred for 30 min. The resulting precipitate was then filtered and washed with Et20 (10 ml.) to afford a yellow solid. This was slurried in Et20 (20 ml.) and filtered to afford methyl 2-(2-(methylsulfonamido)thiazol-4-yl)acetate (3.56 g, 13.94 mmol, 67 % yield) as a colourless solid; Rt 0.83 min (HPLC acidic); m/z 251 (M+H)+ (ES+); 249 (M-H)- (ES-); 1H NMR (400 MHz, DMSO-d6) d 12.47 (s, 1 H), 6.60 (s, 1 H), 3.67 (d, J = 0.9 Hz, 2H), 3.66 (s, 3H), 2.90 (s, 3H).
The synthetic route of 64987-16-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; STEP PHARMA S.A.S.; QUDDUS, Abdul; NOVAK, Andrew; COUSIN, David; CHATZOPOULOU, Elli; BLACKHAM, Emma; JONES, Geraint; THOMAS, Jennifer; WRIGGLESWORTH, Joseph; DUFFY, Lorna; BIRCH, Louise; GEORGE, Pascal; AHMED, Saleh; (277 pag.)WO2019/106156; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica