With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
20 g Ethyl 5-chlorothiazol-4-carboxylate was added to 150 ml ammonia water, and reacted at room temperature with stirring for 5 hr. The resultant reaction mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain 9.5 g of a crude product which was recrystallized from ethyl acetate to obtain 5.8 g of a needle crystal (yield 30%) with mp 213-216C; 1H NMR (DMSO-d6) 7.69(1H,s); 7.83 (1H,s); 9.05(1H,s)., 425392-45-6
As the paragraph descriping shows that 425392-45-6 is playing an increasingly important role.
Reference：
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica