103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
150 mg (0.43 mmol) of 5-bromo-thiazole-4-carboxylic acid and 81.4 mg (0.87 mmol) of pyridin-3-yl-amine were dissolved in 6 ml dimethyl formamide. 0.09 mL (0.65 mmol) of triethyl amine followed by 225 mg (0.43 mmol) of 1H-benzotriazol-1-yloxytri-pyrrolidinophosphonium hexafluorophosphate (PyBOP) were added and the reaction mixture was stirred at room temperature for 16 h. Brine was added and the reaction mixture was extracted two times with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered and the solvent was removed under reduced pressure. The obtained residue was purified by flash column chromatography (silica, gradient elution cyclohexane?ethyl acetate?methanol) to give 90 mg (66%, 90% purity) of the title compound
103878-58-6, As the paragraph descriping shows that 103878-58-6 is playing an increasingly important role.
Reference：
Patent; BASF SE; Le Vezouet, Ronan; Soergel, Sebastian; Defieber, Christian; Gross, Steffen; Koerber, Karsten; Culbertson, Deborah L.; Anspaugh, Douglas D.; US9125414; (2015); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica