With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-86-4,6-Bromo-2-chlorobenzothiazole,as a common compound, the synthetic route is as follows.,80945-86-4
Intermediate 86:N-{6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4-pyrimidinyl}-6-bromo-1,3-benzothiazol-2-amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4-pyrimidinamine (10.8g, 33.8mmol) and 6-bromo-2-chloro-1,3-benzothiazole (8.82g, 35.5mmol) in dry dimethylformamide (20OmL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in oil) (2.7Og,67.6mmol) and the mixture stirred with cooling for 3 hours. The mixture was treated with aqueous ammonium chloride (5%, 20OmL) and ethyl acetate (40OmL). The organic phase was dried over magnesium sulfate, filtered and evaporated to dryness to afford the title compound (17.82g, 33.5mmol, 99% yield). LCMS (Method A): Rt 1.53 minutes; m/z531 ,533 (MH+).
As the paragraph descriping shows that 80945-86-4 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; ALDER, Catherine, Mary; BALDWIN, Ian, Robert; BARTON, Nicholas, Paul; CAMPBELL, Amanda, Jennifer; CHAMPIGNY, Aurelie, Cecile; HARLING, John, David; MAXWELL, Aoife, Caitriona; SIMPSON, Juliet, Kay; SMITH, Ian, Edward, David; TAME, Christopher, John; WILSON, Caroline; WOOLVEN, James, Michael; WO2010/106016; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica