848841-68-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.848841-68-9,4-(4-Chlorothiazol-2-yl)morpholine,as a common compound, the synthetic route is as follows.
Part F: Title compound; A Teflon screw-cap via) is charged with 100 mg (0.40 mmol, 1.0 equiv) of crude 3-chloro-2,5-dimethyI-7-(pentan-3-yI)-5H-pyrrolo[2,3-b]rhoyrazine and 2 mL of DMF. To the solution is added 98 mg (0.48 mmol, 1.2 equiv) of 4-(4-chlorothiazol-2-yI)morphoIine, 21 mg (0.08 mmol, 0.20 equiv) of tripbenylphosphine, 19 mg (0.1 mmol, 0.25 equiv) of copper(I) iodide, 261 mg (0.8 mmoi, 2.0 equiv) of cesium carbonate, and lastly 5 rag (0.02 mmol, 0.05 equiv) of palladium acetate. The reaction vial is evacuated and purged with nitrogen three times before being tightly capped and heated overnight at 1 10 C, The reaction mixture is cooled to it, diluted with water and extracted with EtOAc (3 X 10 mL). The combined organic extracts are washed with brine, dried over NaiSO^ and concentrated under reduced pressure. The resulting residue is purified by preparative thin layer chromatography using 30% EtOAc in hexanes to give the desired compound as a yellow solid (26 mg, 15% yield). MS = 420.08 (M +1). 1H NMR (300 MHz, CDC13) delta 7.22 (IH, s), 3.82-3.85 (4H, m), 3.84 (3H, s), 3.44-3.56 (4H, m), 2.96 (IH, m) 2.70 (3 H, s), 1.73-1 .85 (4H, m), 0.86 (6H, q, J = 7.5 Hz).
The synthetic route of 848841-68-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NEUROGEN CORPORATION; WO2008/83070; (2008); A1;,
Thiazole | C3H3NS – PubChem
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