943-03-3, 6-Methoxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,943-03-3
Pyridine hydrochloride (1.18 g, 10.2 mmol, 10 eq) and 6-methoxy-2-cyanobenzothiazole (0.195 g, 1 .02 mmol, 1 eq) were combined in a rigorously dried sealed tube, purged and placed underan inert nitrogen atmosphere. The reaction mixture was then stirred at 180 00 for 1 h. The resulting red-brown residue was cooled to room temperature and then dissolved in EtOAc (20 mL) and washed with saturated NaHCO3 (1 x 20 mL), 1M HCI (1 x 10 mL), H20 (4 x 10 mL), and brine (1 x 1 0 mL). The organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The crude product was purified using column chromatography eluting with 3:7 EtOAc:Hexane to yield 2-cyano-6-hydroxybenzothiazole as a pale yellow solid. Mp: 202-207 0C (lit. 205-207 oc). 1H-NMR(400 MHz, DMSO) 510.51 (1H, brs, -OH), 7.89 (1H, d, J = 9.0 Hz, H-4), 7.60 (1H, d, J = 2.4 Hz,H-7), 7.19 (1H, dd, J = 9.1, 2.4 Hz, H-5) ppm. 13C-NMR (100.6 MHz, CDCI3) 5160.4(0-2), 147.4(C-6), 139.1 (C-3), 134.0 (0-8), 126.8 (C-7), 119.8 (C-5), 114.4 (C-i), 107.5 (C-4) ppm. MS(ESI+): m/z Calculated for C8H4N2OS [M+H] 177.0122, found 177.0117.
As the paragraph descriping shows that 943-03-3 is playing an increasingly important role.
Reference：
Patent; UNIVERSITY OF CAPE TOWN; JARDINE, Moegamat Anwar; RYLANDS, Marwaan; (60 pag.)WO2019/21202; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica