4175-72-8, 4-Chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4175-72-8
[00258] To a thoroughly degassed stirred solution of tert-butyl (3fl)-4-(5,6-dichloro-2- iodo-pyrimidin-4-yl)-3-methyl-piperazine-1 -carboxylate (3-012, prepared in Scheme 3) (19.0 g, 40.2 mmol), 4-chlorothiazole (4.8 g, 40.2 mmol) and cesium carbonate (19.6 g, 60.2 mmol) in tert-butanol (200 mL) was added tri-tert-butylphosphonium tetrafluoroborate (1 .16 g, 4.01 mmol) and palladium acetate (0.45 g, 2.014 mmol). The reaction was heated to 80 C for 72 h. The reaction mixture was cooled to room temperature, filtered and the filtrate concentrated to dryness to afford a brown oil. This was purified by flash column chromatography on silica gel (eluting with a mixture of ethyl acetate in cyclohexane 0-60%) to give the title compound (3.80 g, 20%) as a yellow powder. LCMS: RT 3.34 min, Ml 466, Method (4LCMS6); NMR (400 MHz, CDCI3) delta 8.75 (s, 1 H), 4.70 (s, 1 H), 4.32 – 3.84 (m, 4H), 3.41 (td, J = 13.9, 13.0, 3.3 Hz, 1 H), 3.17 (s, 1 H), 1 .49 (s, 9H), 1 .37 (d, J = 6.7 Hz, 3H).
4175-72-8 4-Chlorothiazole 13517394, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; CARSWELL, Emma L.; CHARLES, Mark David; EKWURU, Chukuemeka Tennyson; ELUSTONDO, Fred; FOWLER, Catherine M.; OTT, Gregory R.; ROFFEY, Jonathan R; BROOKFIELD, Joanna L.; FORD, Daniel; CALDER, Mathew L.; (159 pag.)WO2018/87527; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica