With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
Step A. Benzothiazole-6-carbonyl chloride. Under anhydrous conditions, a mixture of benzothiazole-6-carboxylic acid (1.0 g, 5.6 mmol) and oxalyl chloride (0.5 mL, 5.6 mmol) in dichloromethane (25 mL) containing a catalytic amount of N,N-dimethylformamide was stirred at ambient temperature for 3 hours. Removal of the solvent in vacuo provided a quantitative yield of the acid chloride as a light brown solid, which was used as such in the next step., 3622-35-3
The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; American Home Products; US6344451; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica