With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1849-73-6,7-Chlorobenzo[d]thiazole-2(3H)-thione,as a common compound, the synthetic route is as follows.
A solution of 5-amino-2-bromo-1 -butyl-1 H-imidazole-4- carboxamide (46 mg, 0.17 mmol), potassium te/t-butoxide (64 mg, 0.52 mmol), lithium bromide (76 mg, 0.8 mmol) and 7-chloro-benzothiazole-2-thiol (86 mg, 0.4 mmol) in 7 ml_ of DMF was stirred at 12O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 10percent) yielded 5-amino-1 -butyl-2- (7-chloro-benzothiazol-2-ylsulfanyl)-1 H-imidazole-4-carboxamide (33 mg, 49percent) as a foam. 1H-NMR [CDCI3, delta, ppm]: 7.73 (m, 1 H), 7.33 (m, 1 H), 7.26 (m, 1 H), 3.89 (m, 2H, CH2N), 1.54 (m, 2H, CH2), 1.37 (m, 2H, CH2), .0.92 (m,
1849-73-6, 1849-73-6 7-Chlorobenzo[d]thiazole-2(3H)-thione 11171663, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
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