824403-26-1, 5-Bromo-2-chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
824403-26-1, Step 1 : 5-Bromo-2-cyclopropylbenzo[ |thiazole [00332] To a solution of 5-bromo-2-chlorobenzo[d]thiazole (0.50 g, 2.02 mmol) and Pd(PPh3)4 (70 mg, 0.06 mmol) in THF (5 mL) was added dropwise cyclopropyl zinc bromide (0.5 M in THF, 4.0 mL, 2.02 mmol), over 15 min. The reaction mixture heated to 60 C under N2 for 1 8 h. The reaction mixture was cooled to 0 C and quenched with saturated sodium hydrogen carbonate solution (1 0 mL). The corresponding solution was partitioned with ethyl acetate (50 mL), washed with saturated sodium hydrogen carbonate solution (30 mL), dried over MgS04 and concentrated to give an orange solid. The crude reaction material was purified by flash silica chromatography (gradient elution /’-hex to 50% EtOAc in /-hex) to give the title compound as a pale yellow solid (0.45 g, 88%). LCMS (ES+) consistent with target (M+H)+.
824403-26-1 5-Bromo-2-chlorobenzo[d]thiazole 20251269, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; MUNOZ-SAN JUAN, Ignacio; MAILLARD, Michel; RAPHY, Gilles; HAUGHAN, Alan, F.; LUCKHURST, Christopher, A.; JARVIS, Rebecca, E.; BURLI, Roland, W.; WISHART, Grant; HUGHES, Samantha, J.; ALLEN, Daniel, R.; PENROSE, Stephen, D.; BRECCIA, Perla; WO2014/159224; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica