Downstream synthetic route of 2942-14-5

2942-14-5 5-Methoxybenzo[d]thiazole 12422200, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2942-14-5,5-Methoxybenzo[d]thiazole,as a common compound, the synthetic route is as follows.

Intermediate 25:[0144] A mixture of intermediate 24 (272 mg, 1.65 mmol) and hydroiodic acid (45%, 2 mL) was heated to reflux for 5 h. The mixture was diluted with water and filtered. The filtrate was neutralized and the solids were filtered, washed with water, and combined to give benzo[c ]thiazol-5-ol (intermediate 25) (206 mg, 83%). HPLC: 99%, RT 2.038 min. MS (ESI) m/z 152.1 [M + H]+., 2942-14-5

2942-14-5 5-Methoxybenzo[d]thiazole 12422200, athiazole compound, is more and more widely used in various fields.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen; WO2012/3418; (2012); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica