40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-aminothiazole-4-carboxylic acid (40 mg, 028 mmol) and HBTU (201 mg, 0.53 mmol) in a mixed solvent of dimethyl sulfoxide (2 mL) and tetrahydrofuran (4 mL) was stirred for 10 min at rt, then (+/-) -cis-6- ( (3-aminocyclohexyl) amino) -2- (5, 7-difluoro-1-tosyl-1H-indol-3-yl) -5-fluoro-4-phenylnicotinonitrile (108 mg, 0.18 mmol) and DIPEA (0.10 mL, 0.61 mmol) were added into the mixture. The resulting mixture was stirred at rt overnight. To the reaction mixture was added water (30 mL) , and the mixture was extracted with EtOAc (30 mL × 3) . The combined organic layers were washed with a saturated aqueous sodium chloride solution (60 mL) , dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo to dry, and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) 5/1 1/5) to give the title compound as a white solid (37 mg, 28 %). 1H NMR (400 MHz, CDCl3) delta (ppm) : 8.67 (s, 1H) , 7.92 (d, J 7.9 Hz, 2H) , 7.71 (dd, J 8.9, 2.2 Hz, 1H) , 7.54 (s, 5H) , 7.32 (m, 3H) , 7.04 (d, J 8.1 Hz, 1H) , 6.85 (ddd, J 11.4, 9.0, 2.3 Hz, 1H) , 5.23 (dd, J 7.8, 2.4 Hz, 1H) , 5.03 (s, 2H) , 4.28 (m, 1H) , 4.03 (m, 1H) , 2.51 (d, J 11.5 Hz, 1H) , 2.39 (s, 3H) , 2.28 (d, J 12.0 Hz, 1H) , 2.12 (d, J 11.1 Hz, 1H) , 1.93 (d, J 14.1 Hz, 1H) , 1.76 (s, 2H) , 1.59 (d, J 13.4 Hz, 1H)., 40283-41-8
40283-41-8 2-Aminothiazole-4-carboxylic acid 1501882, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; ZHANG, Yingjun; (161 pag.)WO2018/41091; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica