31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 22: Compound 52 5-Amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (150mg, 0.806mmol) was dissolved in dichloromethane (3ml_). To this, pyridine (0.195ml_, 2.42mmol) was added at room temperature. To this, benzenesulfonyl chloride (171 mg, 0.967mmol) was added at room temperature and stirred for 16 hours. The mixture was concentrated in vacuo, diluted with water and extracted with ethyl acetate. The organic layer was dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was dissolved in tetrahydrofuran (3ml_) and water (1 ml_). To this, lithium hydroxide monohydrate (101 mg, 2.41 mmol) was added at room temperature and stirred for 12 hours. The mixture was concentrated in vacuo and diluted with water. The mixture was acidified with 1 N hydrochloric acid solution. The product was collected by filtration, washed with diethyl ether and dried under vacuum to give Compound 52 (28mg). 1 H NMR (DMSO-de) delta: 7.85-7.75 (2H, m), 7.70-7.62 (1 H, m), 7.62-7.54 (2H, m), 2.75 (3H, obs) LCMS (Method 30) Rt 4.63 min; m/z(M-H)” 297
31785-05-4, As the paragraph descriping shows that 31785-05-4 is playing an increasingly important role.
Reference：
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica