Brief introduction of 103878-58-6

103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of compound LXXX 2 (0.7 g, 3.37 mmol), compound LXXX-2A (0.53 g, 4.36 mmol), TEA (677 mg, 6.7 mmol) in toluene (10 mL) was added DPPA (1.2 g, 4.36 mmol) under nitrogen. After the addition, the solution was heated to reflux under nitrogen over night. The solution was concentrated. The residue was purified by column chromatography on silica gel (Petroleum ether:EtOAc = 3: 1) to afford compound LXXX-3 (0.76 g, yield 69%). MS (ESI) m/z (M+Na)+ 350.9., 103878-58-6

103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference:
Patent; INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.; WO2013/25733; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica