With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
A mixture of 2-araino-l-(4-methoxyphenyl)ethanone hydrochloride (8 mg, 0.04 mmol), benzothiazole-6-carboxylic acid (7 mg, 0.04 mmol), tris(dimethylamino)chloro phosphonium hexafluorophosphate (48 mg, 0.14 mmol), and N,N-diisopropylethylamine (24 muL, 0.14 mmol) in NMP (600 muL) was stirred at room temperature overnight, then the solvents were evaporated in vacuo. The resulting residue was dissolved in acetic anhydride (400 muL) followed by the addition of TFA (100 muL). The reaction mixture was heated at 90 0C for 1 h, cooled to the room temperature, and concentrated in vacuo. The resulting residue was dissolved in DMSO (200 mul) and subjected to HPLC purification (Method T) to provide 6-(5- (4-methoxyphenyl)oxazol-2-yl)benzo[dJthiazole (2 mg). LC/MS (ESI) m/z 309.1 [M+H]. HPLC retention time (Method A) = 3.53 min., 3622-35-3
3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; AMPHORA DISCOVERY CORPORATION; WO2007/149395; (2007); A2;,
Thiazole | C3H3NS – PubChem
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